Page 16 - N. Metabolism and metabolic diseases

[N. Metabolism and metabolic diseases-8]

Hypoglycemic and Hypolipidemic Effects of HMR (Home

Meal Replacement) with Nondigestible Maltodextrin in

C57BL/KsJ-db/db mice

So-Yeon Ko¹˙#, Ha-Rim Kim¹, Seon-Young Kim¹, Jong-Un Choi², Anna Yu², Ji-Young Yoon¹˙*

¹R&DB Division, Jeonju Agro-Biomaterials Institute, Jeonju 54810, Republic of Korea, ²Hanwoomul, Hanwoomul

Co., Ltd, Gimje 54334, Republic of Korea

In this study we evaluated the effect of frozen rice containing nondigestible maltodextrin on hyperglycemia and
dyslipidemia in type 2 diabetes mice model. C57BL/KsJ-db/m and db/db mice were divided into five groups; non-

diabetic group (ND), diabetic mellitus group (DM), positive control group (PC, rosiglitazone), HMR-type frozen rice
fed group (HFR), and HMR-type frozen rice containing nondigestible maltodextrin fed group (HFRN) for 6 weeks.

Blood glucose, insulin, glycated hemoglobin, oral glucose tolerance test, intraperitoneal insulin tolerance test were
analyzed. HFRN treatment significantly decreased body weight gain, the levels of fasting glucose and postprandial

glucose, and glucose tolerance compared with DM group(P<0.01). HFRN ameliorated insulin resistance with
pancreatic tissues damage in C57BL/KsJ-db/db mice and alleviated hepatic steatosis with reduced liver hypertrophy

and hepatic lipid accumulation. The levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase,
which are known as the indicators liver function, were also remarkably decreased in HFRN group (P<0.01). These

results suggest that HMR-type frozen rice supplemented with nondigestible maltodextrin could be used as
functional foods for improvement of hyperglycemia and dyslipidemia.