Page 12 - N. Metabolism and metabolic diseases

[N. Metabolism and metabolic diseases-6]

The biphasic activity of Lindera obtusiloba extracts in bone

homeostasis through the regulation of osteoclastogenesis

and osteoblast differentiation

Shin-Hye Kim¹˙², Sik-Won Choi¹

¹Forest Biomaterials Research Center, National Institute of Forest Science(NIFS), Jinju 52817, Korea, ²Department of

Biological Sciences, Chonbuk National University, Jeonju 54896, Korea

The number of patients with bone metabolic disorders including osteoporosis is increasing worldwide. These
disorders often facilitate bone fractures, which seriously impact the patient’s quality of life and could lead to further

health complications. Bone homeostasis is tightly regulated to balance bone resorption and formation. However,
many anti-osteoporotic agents are broadly categorized as either bone forming or anti-resorptive, and their

therapeutic use is often limited due to unwanted side effects. Therefore, effective therapeutic agents are needed
for osteoporosis. This study aims to clarify the bone protecting effects of Lindera obtusiloba leaf extract (LOLE) and

its mode of action. LOLE inhibited RANKL-induced osteoclast differentiation by blocking c-Fos/NFATc1. Furthermore,
we found that LOLE enhanced BMP-2-stimulated osteoblast differentiation by the induction of alkaline phosphatase

(ALP). These results showed that LOLE has the potential to combat bone metabolic disorders including osteoporosis