Page 15 - N. Metabolism and metabolic diseases

Hypoglycemic and Hypolipidemic Effects of HMR
(Home Meal Replacement) with Nondigestible Maltodextrin
in C57BL/KsJ-db/db Mice

1
So-Yeon Ko , Ha-Rim Kim , Seon-Young Kim ,Jong-Un Choi , Anna Yu and Ji-Young Yoon 1
1*
1*
2
2
1 Jeonju AgroBio-Materials Institute, Jeonju, Korea, Hanwoomul Co., Ltd, Gimje, Korea
2
BACKGROUND AIM
Nowadays, consumption of home meal replacement(HMR) This study was to confirm the effect on lowering blood
in pursuit of simplicity and convenience is increasing. sugar by administering HMR according to the addition
Nondigestible maltodextrin has been shown to lower blood of nondigestible maltodextrin using type 2 diabetes
sugar, triglyceride, and cholesterol. Therefore, according mice model. Our results provide the useful information
to consumer's desire for healthy food considering taste of the development of high-quality HMR-type frozen
and nutrition, we attempt to develop processed rice that rice products that can prevent diabetes and
has effect on lowering blood sugar . hypertension. .
METHODS

We evaluated the effect of frozen rice containing nondigestible maltodextrin on hyperglycemia and dyslipidemia in
type 2 diabetes mice model. C57BL/KsJ-db/m mice and db/db mice were divided into five groups; non-diabetic group
(ND, non-diabetic control), diabetes mellitus group (DM, diabetic mellitus control), positive control group (PC,
rosiglitazone ), HMR-type frozen rice fed group (HFR), and HMR-type frozen rice with nondigestible maltodextrin fed
group (HFRN, HFR with 3.3% NMD) for 6 weeks. Blood glucose, insulin, glycated hemoglobin (HbA1C), oral glucose
tolerance test (OGTT), and intraperitoneal insulin tolerance tests were analyzed.
RESULTS

HFRN treatment significantly decreased body weight gain, levels of fasting glucose and postprandial glucose,
and glucose intolerance compared with the DM group(P<0.01) HFRN ameliorated insulin resistance with
pancreatic tissues damage (P<0.01) in C57BL/KsJ-db/db mice. In addition, HFRN alleviated hepatic steatosis
based on reduced liver hypertrophy and hepatic lipid accumulation. The levels of glutamic oxaloacetic
transaminase (GOT; AST) and glutamic pyruvic transaminase (GPT; ALT), which are indicators of liver function,
were also remarkably reduced in the HFRN group (P<0.01)
CONCLUSION ACKNOWLEDGEMENTS
These results suggest that HMR-type frozen rice This research was financially supported by the Ministry of
supplemented with non-digestible maltodextrin could Small and Medium-sized Enterprises(SMEs) and Startups
be used as functional foods for improvement of (MSS), Korea, under the “Regional Star-Enterprise Deve-
hyperglycemia and dyslipidemia. lopment Program(R&D,P0010085) supervised by the Korea
In-stitute for Advancement of Techno-logy(KIAT).