Page 14 - X. Stem cell biology

[X. Stem cell biology-9]

Ac-PCP activates skin regeneration and Neovascularization by

EPC

Yang Woo Kwon¹, YOUNG-CHEOL SONG¹, Soon Chul Heo¹, Tae Wook Lee¹, Jae Ho Kim¹

¹physiology, Pusan National University School of Medicine, Yangsan 50612, Korea

Ac-PGP is known as CXCR2 agonist peptide and is involved in cell regulation through IL-8 mechanism. In particular,
the activation of cells involved in vascular regeneration, such as EPC, can be controlled, and this action has also
been confirmed to have a high cutaneous wound healing effect. When processing Ac-PGP in the wound area of

Mouse, neovasculatization and skin regeneration in the round area were activated, especially migration and tubing

formation of EPC were also shown to be activated. The action of this Ac-PGP was shown to halve the skin
regeneration and neovasculation in the wound healing model of CXCR2 knockout mouse, which was also identified
as a reduction in tube formation and EPC migration by CXCR2 knockdown. Based on these contents, Ac-PGP has

been shown to have EPC-derived window healing effects through CXCR2-related mechanism regulation.