Page 17 - X. Stem cell biology

Stem cell spheroids loaded with quercetin microparticles exert potent protective effects against murine
colitis model and induce the generation of wound-healing epithelial cells in intestinal organoids
1,2
1,2
1,2
3
1,2
1,2
Ji-Su Ahn ,Yoojin Seo , Su-Jeong Oh , Ye Young Shin , Ji Won Yang , Jee-Heon Jeong , and Hyung-Sik Kim 1,2
1 Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea
2 Dental and Life Science Institute, Pusan National University, Yangsan 50612, Republic of Korea
3 College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea
BACKGROUND AIM
Tissue repairing capacity and immunomodulatory effects of To investigate the role of heterospheroids in
mesenchymal stem cells (MSCs) have been extensively exploited for the 1. therapeutic effect against DSS colitis model
treatment of various inflammatory disorders; however, low survival rate
after in vivo application often restrain their clinical potential. To overcome 2. homeostasis of intestinal epithelium
these limitations, we designed a novel strategy to create heterospheroids 3. regeneration of intestinal epithelium
(HS).

METHODS

RESULTS

CONCLUSION ACKNOWLEDGEMENTS

This work was supported
by the National Research
Foundation of Korea
(NRF) grant funded by
the Korea government
(MSIT) (No. NRF-
2019R1A2C2085876 ).

Contact

hskimcell@pusan.ac.kr