Page 12 - X. Stem cell biology

[X. Stem cell biology-8]

Ablation of Sirt1 in the non-hematopoietic bone marrow

microenvironment is not required for hematopoietic stem

cell function in the adult mice

Suyeon Woo¹, Jayoung Kim¹, Hee Seon Choi¹, Dongjun Lee¹

¹Department fo Convergence Medicine, Pusan National University, Yangsan 50612, Korea

SIRT1 is known as a histone deacetylase, performs a wide variety of functions in biological systems. It has been
reported that SIRT1 is relevant to stem cell homeostasis including cell proliferation, differentiation, apoptosis, and
inflammatory responses. This SIRT1 plays an important role in delay aging, extending life span, and prevent aging-

related in response to mitochondrial metabolic. The previous study demonstrated that loss of Sirt1 in the
hematopoietic stem and progenitor system regulates the expansion of hematopoietic stem and progenitor cell

population under stress conditions. Also, the SIRT1 activator regulates hematopoietic stem and progenitor cells and
changed the number for hematopoietic stem cells. This study investigated the role of SIRT1 in the non-

hematopoietic bone marrow microenvironment. Ablation of Sirt1 in the non-hematopoietic bone marrow
microenvironment demonstrated that the production of mature blood cells and frequencies of hematopoietic stem

and progenitor cell population attained similar results to those of controls. Moreover, the ablation of Sirt1 in the
non-hematopoietic bone marrow microenvironment did not influence stem cell function under stress conditions.

SIRT1 is dispensable for regulating pools of hematopoietic stem and progenitor cells.