Page 13 - X. Stem cell biology

Ac-PCP activates skin regeneration and Neovascularization by EPC

Yang Woo Kwon, Young-cheol Song, soon Chul Heo, Tae Wook Lee, Jae Ho Kim
Medical Research Center for Ischemic Tissue Regeneration & Medical Research Institute, Department of Physiology,
School of Medicine, Pusan National University, Yang san 626-870, Republic of Korea

BACKGROUND AIM

Ac-PGP is known as CXCR2 agonist peptide and is involved We demonstrated the medicinal effect of
in cell regulation through IL-8 mechanism. In particular, the
activation of cells involved in vascular regeneration, such as collagen-derived tripeptide Ac-PGP on
EPC, can be controlled, and this action has also been wound healing. Ac-PGP treatment
confirmed to have a high cutaneous wound healing effect.
When processing Ac-PGP in the wound area of Mouse, accelerated wound healing with enhanced
neovasculatization and skin regeneration in the round area neovascularrization, and the combination
were activated, especially migration and tubing formation of
EPC were also shown to be activated. The action of this Ac- of hEPCs and Ac-PGP was the most
PGP was shown to halve the skin regeneration and effective. These results may contribute to
neovasculation in the wound healing model of CXCR2
knockout mouse, which was also identified as a reduction in the development of therapeutic products
tube formation and EPC migration by CXCR2 knockdown. for acute and chronic wounds.
Based on these contents, Ac-PGP has been shown to have
EPC-derived window healing effects through CXCR2-related
mechanism regulation.

RESULTS

Figure 1. Effects of Ac-PGP on the migration, tube Figure 2. Role of CXCR2 in the Ac-PGP-induced
formation, and proliferation activities of hEPCs. migration and tube formation of hEPCs.

Figure 6. Effects of combined treatment of Ac-PGP
and hEPC on the cutaneous wound healing and
neovascularization.
REFERENCES

1. Asahara T et al (1997)
Science ; 275:964–967.
2. Hooi JD et al (1999) Br J Gen
Pract ; 49:49–55.
3. Kim SD et al (2011) Am J
Figure 3. Effects of Ac-PGP treatment on the cutaneous
wound healing. Respir Crit Care Med ;
Contact information 184(2):243-251

4. Heo SC et al (2014) Stem
Pusan National University Cells ; 32(3):779-790
Young-cheol Song Figure 5. Effects of Ac-PGP on neovascularization in
the ischemic hindlimbs of bone marrow-
dudcjf1114@naver.com
transplanted mice.