Page 38 - M. Immunology
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[M. Immunology-25]
The open reading frame 5 (ORF5) of porcine circovirus type 2
(PCV2) modulates host innate immunity by suppressing
transcription factors involved in type I interferon signaling
pathway
Na Young Lee¹, Taehoon Chun¹
¹Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea
Porcine circovirus type 2 (PCV2) is detrimental agent causing post-weaning multisystemic syndrome (PMWS) in pig
via reducing host innate immune response. The open reading frame 5 (ORF5) of PCV2 was recently discovered as
a non-structural protein, but its function in PCV2 remains unknown. To examine functional role of ORF5 in host
immunity, we utilized RNA-seq of ORF5-overexpressed host cell. The data revealed that PCV2 ORF5 down-regulates
the innate immune response, especially the transcription factors involved in type I interferon signaling pathway.
Conversely, the transcription factors are up-regulated in ORF5-deleted PCV2 infected cell. Therefore, PCV2 ORF5
may modulate host innate immunity and provide better understanding of the mechanism in PMWS. This work was
supported by a grant from the Next-Generation BioGreen 21 Program (Project No. PJ01327101), Rural Development
Administration, Republic of Korea.
