Page 36 - M. Immunology

[M. Immunology-24]

Lactobacillus plantarum cjlp133 and cjlp243 alleviates the

allergic rhinitis in birch pollen inhaled mouse model

Hyeon jeong Lee¹, Taehoon Chun¹˙*

¹Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea

The health benefits of probiotics are widely used for various purposes, including regulation of the systemic immune
response. In this study, we validated whether CJLP133 and CJLP243 can modulate the immune response in birch
pollen-induced allergic rhinitis mice models. Bronchoalveolar lavage fluid and draining lymph node samples from

Lactobacillus plantarum administrated mice showed decline in the number of immune cells, increase in secretion of

a Th1-type cytokine (IFN-γ) and decrease in production of Th2-type cytokines (IL-4, IL-5 and IL-13). Accordingly,
production of Th2-type cytokines (IL-4, IL-5 and IL-13), Lactobacillus plantarum-administrated mice showed low BP-
specific serum IgG1 and serum IgE, while secretion of IFN-γ and BP-specific serum IgG2a was increased. These

results established that oral administration of CJLP133 or CJLP243 can mitigate the major symptoms of allergic
rhinitis mouse model through enhancing Th1 response while weakening Th2 response. This research was supported

by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the
Ministry of Science & ICT (2017M3A9C8060392), and an intramural research program funded by Korea University

grant (2016).