Page 2 - O. Microbiology

[O. Microbiology-3]

Antibacterial activity of 2-Furanone derivatives against foot

odor causing bacteria Staphylococcus aureus and

Staphylococcus epidermidis

Yong-Jae Kwon¹, Hee-Na Jeong¹, Chae-Rin Kim¹, Jae-Hoon Lee¹, Ji-Min Jang¹, Yo-Han Ko¹, Oh-Rim Kwon¹,

Hae-Ryeong Lim¹˙*, Deug-Chan Lee¹˙*

¹Department of medical biotechnology, College of Biomedical Science, Kangwon National University, Chuncheon-

si, Gangwon-do 200-701, Republic of Korea

Previous research has shown that Staphylococcus epidermidis, Staphylococcus aureus were cultured, after sampling
and incubating samples from the soles of the feet of the stinking man. Suppressing the Staphylococcus epidermidis

and Staphylococcus aureus will help remove foot odor and help keep feet clean. When treated with two strains of
bacteria using 2-Furanone derivatives, the experiment was planned to see how much antibacterial activity they had.

The purpose of this experiment is to find chemicals that suppress and remove Staphylococcus aureus,
Staphylococcus epidermidis that live in the human body especially in the foot. Based on the results of the experiment,

it is to analyze the parent compound and side chain of the two bacteria depending on the level of antibacterial
activity and find out what techniques they can act as antibiotics. 2-Furanone derivatives showed antibiotic effects

on Staphylococcus aureus and Staphylococcus epidermidis, all of which were gram positive bacteria. Antibacterial
activity did not appear in Escherichia coli, a typical example of gram negative. And we did MTT assay to see whether

2-Furanone derivatives were harmful or not when treated at the cell level. So we researched to see if 2-Furanon
derivatives could be used as useful materials.