Page 144 - D. Cancer biology
P. 144
[D. Cancer biology-94]
Inhibitory Effect of Globefish Homogenate on the Growth of
Human Colorectal Cancer Cell Lines
Jung hoon Kim¹, Jung ho Kim¹˙*
¹Laboratory of Molecular and Cellular Biology, Department of Life Science, Sogang University, Seoul 04107, Korea
Cancer is one of the most serious public health problems in Korea and worldwide, and has a major impact on
society. Despite significant advances in traditional anti-cancer therapies, such as chemotherapy, radiotherapy, and
surgery, it remains extremely difficult to cure and prevent cancer. Consequently, novel anti-cancer therapies must
be developed. We previously reported that Globefish homogenate suppresses the growth of Caco-2 human
colorectal cancer cells. To build upon this previous observation, we investigated the cytotoxic effects of Globefish
homogenate on DLD-1, HCT116, and SW480 human colorectal cancer cells by counting cells and examining
morphological changes underneath an inverted microscope. Treatment with Globefish homogenate markedly
inhibited the growth of cultured DLD-1, HCT116, and SW480 cells in a dose-dependent manner. The sensitivities of
these cells to Globefish homogenate were determined by calculating the lethal concentrations. The 50% inhibitory
concentrations of Globefish homogenate were 111, 95, and 121 μg/ml in DLD-1, HCT116, and SW480 cells,
respectively. These results indicate that Globefish homogenate contains a bioactive material(s) that inhibits the
growth of human colorectal cancer cells
