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고형암 항암치료 환자의 부작용 관리 Nausea and Vomiting

2) High emetic risk parenteral anticancer drug

Option 1일 2,∙3,∙4일
A •Olanzapine 5-10 mg PO once • Olanzapine 5-10 mg PO daily on days 2, 3, 4
•NK1 RA (택일) • Aprepitant 80 mg PO daily on days 2, 3 (1일째
- Aprepitant 125 mg PO once aprepitant PO 사용한 경우)
- Aprepitant 130 mg IV once • Dexamethasone 8 mg PO/IV on days 2, 3, 4
- Fosaprepitant 150 mg IV once
- Netupitant 300 mg / palonosetron 0.5mg PO
once
- Rolapitant 180 mg PO once
•5-HT3 (택일)
- Dolasetron 100 mg PO once
- Granisetron 10 mg SQ once, or 2mg PO
once, or 0.01mg/kg IV once, or 3.1 mg/24-h
transdermal patch (첫 투약 24-48h 전 부착)
- Palonosetron 0.25 mg IV once
•Dexamethasone 12 mg PO/IV once
B •Olanzapine 5-10 mg once • Olanzapine 5-10 mg PO daily on days 2, 3, 4
•Palonosetron 0.25 mg IV once
•Dexamethasone 12 mg PO/IV once

C •NK1 RA (택일) • Aprepitant 80 mg PO daily on days 2, 3 (1일째
•5-HT3 RA (택일) aprepitant PO 사용한 경우)
•Dexamethasone 12 mg PO/IV once • Dexamethasone 8 mg PO/IV on days 2, 3, 4

3) Moderate emetic risk parenteral anticancer drug

Option 1일 2,∙3일
A •5-HT3 (택일) •Dexamethasone 8 mg PO/IV on days 2,3
- Palonosetron 0.25 mg IV once prefered 또는
•Dexamethasone 12 mg PO/IV once •5-HT3 RA monotherapy (택일)
- Granisetron 1-2 mg PO daily, or 0.01 mg/kg
(max 1 mg) IV daily on days 2, 3
- Ondansetron 8 mg PO bid or 16 mg PO daily
or 8-16 mg IV daily on days 2, 3
- Dolasetron 100 mg PO daily on days 2, 3
B •Olanzapine 5-10 mg once •Olanzapine 5-10 mg PO daily on days 2, 3, 4
•Palonosetron 0.25 mg IV once
•Dexamethasone 12 mg PO/IV once
C •NK1 RA • Aprepitant 80 mg PO daily on days 2, 3
•5-HT3 RA (1일째 aprepitant PO 사용한 경우)
•Dexamethasone 12 mg PO/IV once •Dexamethasone 8 mg PO/IV on days 2, 3

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