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List of mutations identified in Dec 20, 2020 COG-UK report and BioFire RP2.1 assay reactivity summary

Mutation BioFire RP2.1 BioFire RP2.1
Nucleotide Amino Acid SARSCoV2-2 Assay: SARSCoV2-1 Assay: Overall Result
M-gene (Membrane) S-gene (Spike) Expected
ORF1ab
ACT3263ATT T1001I
GCT5384GAT A1708D Detection
Not targeted Not targeted
ATA6950ACA I2230T Unaffected
TCTGGTTTT11284 Δ3675-7 SGF
Spike
ACATGT21763 Δ69-70
TTA21991 Δ145
AAT23063TAT N501Y Primers unaffected
(Assay located in a
AAT23063TAT N501Y
different area of
CCT23602CAT P681H the gene) Detection
Not targeted
ACA23707ATA T716I Unaffected
TCA24505GCA S982A
Located in 5' end of one
GAC24913CAC D1118H primer; no effect on
performance expected.

ORF8
CAA27969TAA Q27 stop
Detection
AGA28044ATA R52I Not targeted Not targeted
Unaffected
TAC28107TGC Y73C
N
GAT28277CTA D3L Detection
Not targeted Not targeted
TCT28973TTT S235F Unaffected
주의: BioFire RP2.1 Panel (제품번호: 423738)의 사용 목적은 새로운 돌연변이를 모니터링하기 위한 것이 아니며, 변종에 감염된 실제 환자 검
체를 이용한 검증이 아님

RESPIRATORY 2.1 PANEL (EUA): 1 Test, 22 Targets, ~45Minutes.
Overall 97.1% sensitivity and 99.3% specificity (prospective specimens)
SARS-CoV-2 98.0% sensitivity and 100% specificity (archived specimens)
SARS-CoV-2 100% PPA and 100% NPA (contrived specimens)
Sample Type: Nasopharyngeal swab in transport media
VIRUSES: BACTERIA:
•Adenovirus •Bordetella parapertussis
•Coronavirus HKU1 •Bordetella pertussis
•Coronavirus NL63 •Chlamydia pneumonia
•Coronavirus 229E •Mycoplasma pneumoniae
•Coronavirus OC43
•Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
•Human Metapneumovirus
•Human Rhinovirus/Enterovirus
•Influenza A
•Influenza A/H1
•Influenza A/H3
•Influenza A/H1-2009
•Influenza B
•Parainfluenza Virus 1
•Parainfluenza Virus 2
•Parainfluenza Virus 3
코로나바이러스감염증-19 [핵산증폭법] 응급용 선별검사 Ⅲ
•Parainfluenza Virus 4
•Respiratory Syncytial Virus (COVID-19를 포함한 호흡기 바이러스, 폐렴원인균)