Page 4 - Q. Neuroscience

[Q. Neuroscience-3]

Characterization of dysregulated subcellular localization of

disease-related proteins of neurodegenerative diseases in

Drosophila

Yeonjin Jeong¹, Jeong Hyang Park¹, Chang Geun Chung¹, Sung Bae Lee¹˙*

¹Brain and Cognitive Sciences, DGIST (Daegu Gyeongbuk Institute of Science and Technology), Daegu 42988,

Korea

For proper functioning of proteins, subcellular localization of proteins is very important. In fact, dysregulation of
subcellular localization appears to be associated with many diseases. Particularly, mislocalization of disease-related

proteins, such as TDP-43 and polyQ proteins, has been well recognized in neurodegenerative diseases. However,
our understanding on what cellular condition facillitates this mislocalization and what are underlying cellular and

molecular mechanisms remains largely elusive. In this study, we observed dynamic changes in subcellular localization
of disease-related proteins for neurodegenerative diseases along development in Drosophila neurons and

characterized underlying cellular mechanisms. We believe that our findings will be of help for better understanding
of pathophysiology underlying neurodegenerative diseases associated with protein mislocalization.