Page 10 - K. Development and regeneration

[K. Development and regeneration-8]

YAP signaling regulations in CVP morphogenesis

Tae Young Kim¹, Ji Youn Kim², Yam Prasad Aryal¹, Eui Seon Lee¹, Elina Pokhael¹, Chang Hyeon An¹,
Hitoshi Yamamoto³, Wern Joo Sohn⁴, Jae Kwang Jung¹, Jae Young Kim¹

¹Biochemistry, School of Dentistry, IHBR, Kyungpook National University, Daegu 41940, Korea, ²Dental Hygiene,

Gachon University, Incheon 21936, Korea, ³Histology and Developmental Biology, Tokyo Dental College, Tokyo
101-0061, Japan, ⁴Pre-Major of Cosmetics and Pharmaceutics, Daegu Hanny Univesity, Gyeongsan 38610, korea

Tongue is centrally located in oral cavity with its dorsal surface covered with plenty of the specialized papillae, which

accommodate the taste sensation including fungiform, foliate, and circumvallate. Though circumvallate papillae have
been extensively studied to determine the regulatory mechanisms during histomorphogenesis and homeostasis, it

still remains to be elucidated the principle mechanisms of signaling regulations on morphogenesis. clearly
established. Yes-associated protein 1 (YAP1) is the key regulator of the Hippo pathway, which is mainly involved in

regulation of tissue homeostasis, organogenesis, regeneration and tumorigenesis. In this study, we examined the
precise expression pattern and developmental function of YAP to define the fundamental signaling regulations in

CVP morphogenesis. Particularly, we examined the involvement of YAP in development and homeostasis of taste
bud by clarifying the immunohistochemtry localization patterns of YAP and the related markers in taste buds within

cirvumvallate papillae. Overall, we establish the interactive mechanisms in regulating the formation and maintenance
of taste bud by comparing the localization patterns of YAP with those signaling effectors.