Page 14 - K. Development and regeneration

[K. Development and regeneration-10]

Development and evaluation of triple layer skin phantom

model for continuous glucose monitoring system

Seoku Bae¹, YeonJae Baek¹, Subin Bak¹, Sun ju Lee¹, Jiyun Kim¹, Min Woo Lee¹, Jeongsu Choi¹, Unchul Shin¹,
Suhng Wook Kim¹

¹School of Health and Environmental Science, College of Health Sciences, Korea University, Seoul 02841, Republic

of Korea

Continuous glucose measurement system (CGMS) is actively researched for preventing hypoglycemic shock of
patients with type 1 diabetes by glucose monitoring in interstitial fluid. The aim of this study was to develop a triple

layer artificial skin phantom for evaluation of sensor insertion ability and physical characteristics of CGMS sensor.
Epidermis layer was fabricated by special silicone having a shore A value of 0.1 to 5, and dermis layer was fabricated

by 7%~40% gelatin. Subcutaneous fat layer was prepared by fixing with 0.5% agarose gel. Triple layer phantom,
which is composed of 15% gelatin-based shore A 0.3 silicon showed the most similar elasticity compared to under-

arm region as elasticity value of about 1.23±0.01 MPa, and 40% gelatin-based shore A 5 silicon showed the most
similar elasticity compared to under-arm region as elasticity value of about 1.82±0.01 MPa. Triple layer phantom,

which is composed of 40% gelatin-based shore A 0.3 silicon showed the most similar elasticity compared to human
mean elasticity as elasticity value of about 1.45±0.01 MPa. The triple layered artificial skin phantoms are expected

to utilize as an assessment tool in development of CGMS.