Page 80 - I. Chemical biology and drug discovery

[I. Chemical biology and drug discovery-43]

Effect of MJ22 polymeric micelles on antidiabetic target

protein tyrosine phosphatases

Min-Ji Kang¹˙#, Sun-Young Yoon¹˙#, Sang J. Chung¹˙*

¹School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea

Micelles are nanoparticles as be used for targeted drug delivery. Targeting drug delivery systems such as liposomes
and polymeric micelles make numerous chemotherapeutics available that are too toxic to use. Drug-loaded micelles
enhance water solubility and circulation time of drugs. Furthermore, they are able to target specific tissues via

enhancing permeability and retention effect. To improve the antidiabetic effect using these effects, we have made

micelle using MJ22, MJ42, and MJ14. MJ42 is an amphipathic compound, thus it performs the packing behavior.
MJ14 is an antidiabetic substance selected according to bioinformatics and helps to form micelles. MJ22 inhibited
protein tyrosine phosphatases (PTPs) that have been known for antidiabetic target such as SHP2, PTP-MEG2, DUSP9,

TC-PTP in vitro. MJ22 micelles, MJ22, and MJ14 did not exhibit cytotoxicity in C2C12 cells. These results suggest
MJ22 polymeric micelles are a potential therapeutic candidate for diabetes.