Page 78 - I. Chemical biology and drug discovery

[I. Chemical biology and drug discovery-42]

JS-003 as a novel palliative natural compound of type 2

diabetes which is proved to promote glucose-uptake ability

Jin-Soo Kim¹˙#, Sun-Young Yoon¹˙#, Sang J. Chung¹˙*

¹SCHOOL OF PHARMACY, sungkyunkwan university, SUWON 16419, REPUBLIC OF KOREA

In recent society, there are many metabolic diseases including diabetes which is representative of chronicle diseases
consist of two types: Type 1 diabetes and Type 2 diabetes. In terms of type 2 diabetes, It stems from the disability
of glucose-uptake in cells related to insulin receptors as well as glucose transporters. Cell signalings induced by

phosphorylation and dephosphorylation have a strong effect on expressing and translocation of these receptors

and transporters. In this aspect, phosphatases play a significant role in type 2 diabetes. PTP-MEG2 belongs to the
protein tyrosine phosphatase family which is well known for alleviating insulin resistance via insulin transduction
pathway. JS-003 have been sorted as a strong inhibitor of PTP-MEG2 according to our lab database containing

inhibition ability of 658 natural compounds in human-derived phosphatase. We conducted on research to determine
IC50 value which represents inhibition ability of JS-003 in PTP-MEG2 followed by experiments to probe the efficacy

of JS-003 for improving glucose-uptake ability in mammalian cells. Our results of experiments show that JS-003 is
a potential therapeutic compound for type 2 diabetes.