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[H. Cell signaling-18]

The autophagy regulator p62 controls PTEN-dependent cilia

assembly

Minah Park¹, Eun Ji Lee¹

¹Department of Biological Science, Sookmyung Women's University, Seoul 04310, South Korea

Autophagy is a catabolic process required for maintaining intracellular energy homeostasis. It eliminates harmful
proteins and recycles functional macromolecules back into the cell via cargo breakdown. Autophagy is generally
suppressed under fed conditions and induced by serum starvation; therefore, it is considered to be a nutrient-

sensing mechanism. Cilia, finger-like organelles harboring multiple receptors along their surface, are energy-sensing

structures that are also triggered by serum deprivation. Herein, we verified the effect of autophagy alterations on
ciliogenesis and the specific underlying mechanisms. Autophagy flux altered either by drugs or autophagy-targeting
siRNAs strongly inhibited ciliogenesis, and this inhibition was affected by p62, an autophagy regulator, via

Pten/Dvl2/AurKA pathways.