Page 16 - G. Cell differentiation. division. and death

[G. Cell differentiation, division, and death-12]

Downregulation of survivin by ginsenosdie CK increased anti-

cancer effect in human malignant neuroblastoma cells

Jung-Mi Oh¹˙², Sun Young Park¹˙², Sungkun Chun¹˙²

¹Department of Physiology, Jeonbuk National University Medical School, Jeonju 54907, South Korea, ²Brain Korea

21 Plus Program, Jeonbuk National University Medical School, Jeonju 54907, South Korea

Neuroblastoma is a solid tumor that mostly in children. Malignant neuroblastoma have poor prognosis because
conventional chemotherapeutic agents are hardly effective. Survivin is a member of the apoptosis family protein

inhibitor and is involved in tumor cell survival and invasion and differentiation. In neuroblastoma, survivin is highly

upregulated and correlated with poor prognosis. This study, we investigated the effect of CK on survivin
downregulated neuroblastoma cells. CK treatment induced of neuronal differentiation and apoptotic cell death, and
inhibited cell metastasis. In addition, the combination therapy with siRNA survivin was very effective in inducing

the morphological and biochemical feature of apoptosis, respectively. Overall, combination therapy with CK and
knockdown of survivin may be a potentially effective agent in the treatment of neuroblastoma