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[G. Cell differentiation, division, and death-11]
Autophagy regulates formation of primary cilia in
ginsenoside Rk1 treated neuroblastoma cell
Jung-Mi Oh¹˙², Sungkun Chun¹˙²
¹Department of Physiology, Jeonbuk National University Medical School, Jeonju 54097, South Korea , ²Brain Korea
21 Plus Program, Jeonbuk National University Medical School, Jeonju 54097, South Korea
Autophagy is a complex process of cellular degradation and recycling of cytoplasmic proteins and organelles, and
play an important role in cellular homeostasis. Primary cilia are conserved cellular organelles that regulate diverse
signalling pathway. Despite its potential importance, the relationship between autophagy and ciliogenesis in
neuroblastoma is largely unknown.
In this study, we investigated the effect of autophagy induced by Rk1on the formation of primary cilia in
neuroblastoma cells. Rk1 treatment on neuroblastoma cells increased the number of LC3-puncta and LC3-II protein
conversion. In addition, treatment of Rk1 resulted strong elongation of primary cilium and increased the number of
ciliated cells in neuroblastoma cells. Taken together, our results suggest that autophagy induced by Rk1 is positively
affects ciliogenesis in neuroblastoma cells.
