Page 26 - A. Aging

[A. Aging-14]

Senolytic drug improve the skin pigmentation

Ji Hee Park¹˙², Jung Eun Yoon¹, Young-Kyoung Lee¹, Tae Jun Park¹˙²˙³˙*

¹Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea, ²Biomedical

Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea, ³Institute on Aging, Ajou University
Medical Center, Suwon 16499, Korea

Cutaneous aging process is an important extrinsic factor which modifies the pigmentary system. Given that cellular

senescence is a fundamental aging mechanism, we examined the role of senescent cells in aging pigmentation and

found that senescent fibroblasts accumulate at the sites of age-related pigmentation and alter melanocyte
differentiation via stromal-epithelial interactions during aging. Senolytic drugs can induce apoptosis in senescent,
but not in non-senescent cells. ABT263, one of the senolytic drug, it can induce apoptosis in senescent cells which

accumulate in many tissues that aging. ABT263 did not involve in melanin synthesis in melanocytes, however, it
decreased melanocytes pigmentation via regulation of senescent fibroblasts apoptosis. We expected that senolytic

drug, especially ABT263, induce apoptosis in senescent cell and that regulate the skin pigmentation.