Page 290 - ebook
P. 290
[F. Others] F-2
Expression of c-Jun and KROX-20 on facial nerve
degeneration and regeneration in a rat model
Seung Geun Yeo¹, In Hyeok Kim¹, Jae Min Lee¹, Dong Choon Park²*
¹Otorhinolaryngology, Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul 02447, Korea,
²Obstetrics and Gynecology, St. Vincent’s Hospital, The Catholic University of Korea, Suwon 93, Korea
Purpose: This study evaluated the expression of Krox-20 and c-Jun, which have been associated with facial nerve
regeneration after facial nerve compression and cutting, on recovery from facial paralysis. Methods: The left facial
nerves of 24 male Sprague-Dawley (SD) rats aged six weeks were subjected to crushing or cutting injury. The facial
nerves on both sides were removed, and the expression of c-Jun and Krox-20 proteins was evaluated by Western
blotting. Results: Both whisker movements of the vibrissae muscle and blink reflexes of the eyelids 4 and 14 days
after facial nerve injury showed greater improvements in the crushing than in the cutting group, with the difference
in facial nerve recovery on day 14 being significantly higher in the crushing group, as shown by whisker movements
and blink reflexes (p
