Page 184 - ebook

[B. Cell Biology/Stem Cell] B-27

Novel function of SGK1 in shear stress induced endothelial

inflammation

Ye-eun Jang¹

¹Biological sciences, Inje University, Gimhae-si 50834, Korea

SGK1 (serum and glucocorticoid inducible kinase) is reported to promote cell survival by its anti-oxidation activity
in endothelial cells. Additionally, it is also implicated in inflammatory signaling via PI3K, MR (mineralocorticoid

receptor) and NF-kB-dependent pathway. Here, we found that SGK1 is trascriptionally induced by oscillatory shear
stress and mediates pro-inflammatory response in endothelial cells. Several candidate receptors responsible for

SGK-1 induction have been tested and ALK-1(Activin A Receptor Like Type 1) knockdown completely abrogated
flow-induced SGK-1 induction and NFkB-dependent inflammatory activation. These results suggest a novel flow-

induced endothelial inflmmation pathway and therapeutic targets for vascular inflmmatory diseases such as
atherosclerosis.