Page 46 - N. Metabolism and metabolic diseases

[N. Metabolism and metabolic diseases-26]

Ginsenoside Compound K regulates adipogenesis in vitro and

in vivo

SUN YOUNG PARK¹˙², SUNG KUN CHUN¹˙²˙*

¹Department of Physiology, Jeonbuk National University Medical School, Jeollabuk-do, Jeonju-si 54907, Korea,

²Brain Korea 21plus Program, Jeonbuk National University Medical School, Jeollabuk-do, Jeonju-si 54907, Korea

Panax ginseng has been used as a natural medicine and the main component ginsenosides were reported that it
have many therapeutic effects for cancer, diabetes, obesity and neurological diseases. Recently, several studies

showed that some types of ginsenosides have anti-obesity effects. However, ginsenoside Compound K’s effect on

obesity or lipid metabolism was not reported yet. In this study, the effects of compound K on lipid metabolism
were investigated through in vivo and in vitro assays. 3T3-L1 was differentiated with or without CK treatment and
the related genes or proteins were examined. In addition, white adipose tissue (WAT) and brown adipose tissue

(BAT) from C57BL/6 mice was used to confirm CK’s regulating effects on adipogenesis of both tissues. As a result,
CK treatment regulated the differentiation of 3T3-L1 cells via concentration-dependent manner. Intraperitoneal CK

injection (10mg/Kg, 10 days) increased expression of UCP-1 and PPAR-γ mRNA level in WAT as well as reduced the
size of lipid droplets in WAT of CK treated groups (n=5) compared to the vehicle treated groups (n=5). In conclusion,

these data suggests ginsenoside CK treatment can induce transition from white adipocytes to beige adipocytes and
have potentials for treatment of obesity or metabolic disorders