Page 47 - N. Metabolism and metabolic diseases

Truncated SOCS3 (ΔSOCS3) Overcomes Insulin Resistance
Associated with Type 2 Diabetes

Hyeontae Kang, Kuysook Lee, Jisook Jeon, Sujeong Kim, Jeonghoon Kwak, Youngsil Choi and Daewoong Jo
Metabolic Disease Team, Cellivery R&D Institute, Cellivery Therapeutics, Inc., Seoul 03929, Korea

BACKGROUND AIM
Leptin, an adipocyte-derived hormone signals though the JAK/STAT Develop protein-based anti-obesitic and anti-diabetic agent, cell-
pathway and enhances insulin sensitivity. Leptin signaling is permeable truncated SOCS3 (CP-ΔSOCS3) may be useful to treat
negatively regulated by Suppressor Of Cytokine Signaling 3 (SOCS3) the diseases associated with an obesity and diabetes by utilizing
that binds to the leptin receptor ObR and promotes leptin resistance, therapeuticmolecule systemic delivery technology (TSDT).
further associated with hyperinsulinemia and insulin resistance.

METHODS
ΔSOCS3 protein to deliver the protein into cultured cells and animal tissues and a protein solubilization domain to facilitate large-scale
purification of soluble, biologically active proteins. Intracellular delivery of ΔSOCS3 was tested in diet-induced obesity (DIO) mice to evaluate the
increment of insulin sensitivity and glucose control.

RESULTS

CONCLUSION REFERENCES Contact information
Chung et al. (2020) Science Advances, 6: eaba 1193 Minyong Jung
CP-ΔSOCS3 reduces body weight & lipid Lim et al. (2013) Clinical Cancer Research, 19: 680-690
accumulation in diet-induced obesity mouse New Drug & Business Development
model. CP-ΔSOCS3 recombinant protein has Lim et al. (2013) Biomaterials, 34: 6261-6271 Cellivery Therapeutics, Inc.
therapeutic effect on obesity and blood glucose Lim et al. (2012) Molecular Therapy, 20: 1540-1549
control so that it may provide a mechanism- Jo et al (2005) Nature Medicine, 11: 892-898 jungmy@cellivery.com
specific therapy for type 2 diabetes mellitus.
Jo et al (2001) Nature Biotechnology, 19: 929-933 +82-2-3151-8900