Page 2 - N. Metabolism and metabolic diseases

[N. Metabolism and metabolic diseases-1]

Gymnaster koraiensis extract alleviated metabolic syndrome

symptoms in diet induced obese mice

Da Seul Jung¹˙², Yang-Ju Son¹, Ji Min Shin¹, Saruul Erdenebileg¹, Chang Ho Lee², Chu Won Nho¹

¹Smart Farm Reserch Center, Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural

Products, Gangneung Gangwon-do, Korea, ²Biology, Gangneung-Wonju National University, Gangneung
Gangwon-do, Korea

Metabolic syndrome is a medical condition that at least three of pathologic risk factors co-occurred among

abdominal obesity, insulin resistance, hypertension, hyperglycemia and hyperlipidemia. Gymnaster koraiensis (GK)

is known for its beneficial effects about anti-cancer, anti-oxidative stress, and protecting liver injury; but its efficacies
on obesity and metabolic syndrome have not been determined yet. This study examined the effects of GK extract
on obesity and metabolic syndrome in diet induced obese (DIO) mice model. Administration of GK extract to DIO

mice reduced body weight and ameliorated fasting blood glucose, obesity-related inflammation, and oxidative
stress. Moreover, GK extract elevated energy expenditure in white adipose tissue by upregulating AMPK signaling.

In conclusion, GK extract treatment prominently ameliorated metabolic syndrome related symptoms like obesity,
hyperlipidemia, hyperglycemia, and insulin resistance. Hence, GK extract can be a promising therapeutic agent with

multi-target improvement of metabolic syndrome related symptoms.