Page 209 - ebook

Adhesion related molecule X Is elevated in Parkinson’s Disease
Models and affects to pathogenesis of sporadic PD cases

Mihee Oh , Jeong-Su Byun , Seonha Lee , Baek-Soo Han ¹,²*
¹,²
¹
¹
1 Biodefense Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
2 Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34141, Korea
Abstract : Parkinson’s disease (PD) is characterized by the degeneration Introduction
of dopaminergic neurons in the substantia nigra, but the genes
mediating the neurodegenerative processes remain to be fully elucidated.
Here, we generated iPSC lines from several patients with sporadic PD
(SPD) and differentiated into dopaminergic neuron. In this study, we
observed some Parkinson's disease pathological phenotype in
Parkinson’s disease cellular Models. And we suggest that adhesion
related molecule X and its regulatory pathways as potential targets to
suppress the progression of neuron death and degeneration in sporadic
PD. Thus, our study provides an iPSC-based in vitro model that captures
the patients’ genetic complexity and allows investigation of the
pathogenesis of sporadic PD cases.
1. Production of iPSC derived from Parkinson’s disease 2. Analysis of specific gene expression in 3. Analysis of elevated expression of A in a
patient somatic cells dopaminergic neurons derived from cellular model of Parkinson's disease
somatic cells of a normal and Parkinson’s
disease patient

4. A negatively modulates mitochondria membrane potential. 5. Analysis of the relationship between synaptic plasticity
and A in Parkinson's disease cellular model

6. Identification of the relationship between A and the signal transduction
pathway
Conclusion

A is attributable to the pathogenesis of Parkinson's
disease by disrupting synaptic plasticity through
relationships with several signaling molecules.