Page 70 - ebook

[B. Cell Biology/Stem Cell] B-35

Novel function of SHANK3 on vascular inflammation and

atherosclerosis

Jinri Lee¹

¹biotechnology, Inje University, Gimhae-si 50834, Korea

Shank protein constitutes PSD in neurons and is a scaffolding protein that interacts with various proteins such as
GPCR, neurotransmitter receptor, and actin cytoskeleton. In addition to neurons, it is expressed in many other tissues

such as the intestine, breast, kidney, and vasculature, and has been shown to function as a signal transducer in
multiple cell types. Recently, we investigated the effect of extracellular matrix (ECM) proteins on disturbed flow-

induced phospho-proteome and identified Shank3 as a PP2A target whose phosphorylation decreased on
fibronectin, a pro-inflammatory ECM. Interestingly, Shank3 deficiency showed an increase in flow-induced

inflammation in endothelial cells. Therefore, we suggest a novel function of Shank3 on vascular inflammation and
atherosclerosis.