Page 64 - Q. Neuroscience
P. 64
[Q. Neuroscience-38]
Role of Snf7-3 in neurodevelopment and object location
memory
Hyopil Kim¹, Su-Eon Sim¹, Myung Won Kim¹, Jisu Lee¹, June hyun Jeong¹, Yu-Kyung Lee², Jin-A Lee²,
Yongmin Sung¹, Bong-Kiun Kaang¹
¹School of Biological Sciences, Seoul National University, Seoul 08826, Korea, ²Department of Biotechnology,
Hannam University, Daejeon 305-811, Korea
Formation of dendritic architecture is actively regulated during developmental stage, and the disruption of this
control has been related to several neurodevelopmental disorders. Snf7-3, a subunit of endosomal sorting
complexes required for transport III (ESCRTⅢ), is known to be required for regulating dendrite pruning. In this study,
we show that Snf7-3 is mostly expressed during dendritic development stage, and Snf7-3 knockdown leads to
increased dendritic branching in vitro. We then generated KO mouse line in which Snf7-3 is selectively knocked out
in CaMKIIα-expressing excitatory neurons. Snf7-3 KO mice show impaired object location memory. Moreover, higher
miniature excitatory postsynaptic current(mEPSC) frequency, not amplitude, was observed in the hippocampus.
These results suggest Snf7-3, a key component of dendritic development modulation, has a potential role in learning
and memory.
