Page 62 - Q. Neuroscience
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[Q. Neuroscience-37]
REV-ERBα and its impact on hippocampal synaptic plasticity
Ja Eun Choi¹, Somi Kim¹, Jisu Lee¹, Kyungjin Kim², Yeon Jun Kim¹, Bong-Kiun Kaang¹˙*
¹School of Biological Sciences, Seoul National University, Seoul 08826, Korea, ²Department of Brain and Cognitive
Sciences, DGIST, Daegu 42988, Korea
The phenomenon of 24h oscillations is a result of the circadian rhythms which is driven by circadian oscillators. It
has been previously reported, that the circadian rhythms have a role in learning and memory. One of the primary
genes regulating the circadian rhythm is the Rev-ERBα; the nuclear receptor. Rev-ERBα is a transcriptional repressor,
and a core clock protein of biological rhythm. Although the main role of Rev-ERBα has been previously studied, its
role in synaptic plasticity remains elusive. To further assess the relationship between circadian rhythms and synaptic
plasticity in the hippocampus, we used REV-ERBα knock-out (KO) mice in this study. Unparalleled to wild-type
littermates, the REV-ERBα repressed mice showed abnormality in NMDAR-dependent synaptic potentiation (E-LTP)
at CT12-CT14 (subjective night). Despite these abnormalities, during CT0-CT2(subjective day) the KO mice also
showed normal E-LTP, and normal late LTP (L-LTP) at CT12-CT14 and CT0-CT2. These results suggest that Rev-ERBα
has a vital effect in the hippocampal E-LTP during the dark period.
