Page 68 - M. Immunology

[M. Immunology-40]

Dracocephalum moldavica L. seed oil ameliorates DNCB-

induced atopic dermatitis-like symptoms in mice model

Jaeyoung Choi¹, Eunsu Song¹, Kyo-Yeon Lee², Sung-Gil Choi², Su Kang Kim³, Hui Jin⁴, Yun Hee Chang¹,
Jinah Hwang¹

¹Department of Food and nutrition, Myongji University, Yongin 17058, Korea, ²Department of Food Science and

Technology, Gyeongsang National University, Jinju 52828, Korea, ³Department of Biomedical Laboratory Science,
Catholic Kwandong University, Gangneung 25601, Korea, ⁴Center of Nutraceutical and Pharmaceutical Materials,
Myongji University, Yongin 17058, Korea

Dracocephalum moldavica L. (DM) has unique nutritional characteristics in terms of lipid profile and various
polyphenols. Due to its nutraceutical characteristics, DM has been used for dermal problem as an alternative

medicine in Eastern Europe. However, a very few studies focused on analysis of its polyphenolic content using aerial
parts such as leaves and flower by traditional or classical extraction processes. This study was conducted to

determine anti-inflammatory and anti-atopic effect of DM seed oil. After 4 weeks treatment with DM seed oil (2.5,
5, and 10% v/v in olive oil) in atopy-induced Balb/c mice model, increase of epidermal layer and hyperkeratosis was

observed in atopy-induced group (5 % DNCB only), whereas epidermal layers in 2.5-10% DM seed oil recovered to
similar level of naive group and positive control. In terms of SCORAD index, 10% DM seed oil treated group

decreased the indexes by 78% in edema and by 60% in pruritus and dry skin compared to vehicle group. Especially,
the highest DM seed oil concentration (10% DM seed oil) showed more effective in pruritus and dry skin than

DNCB treated group. Consequently, further researches based on DM seed oil may be potentially applied to food or
cosmetic industries due to its anti-atopic effect.