Page 22 - L. Genetics and genomics

[L. Genetics and genomics-19]

Association of Genetic variants in long non-coding RNA

SOX2OT with risk of gastric cancer

Gang Min Hur¹, In Ae Chang¹, Jang Hee Hong¹˙²

¹Department of Pharmacology, Chungnam National University College of Medicine, Daejeon 35015, Republic of

Korea, ²Clinical Trials Center, Chungnam National University Hospital, Daejeon 35015, Republic of Korea

Long non-coding RNAs (LncRNAs) have been suggested that are associated with cancer progression. In this study,
we evaluated the association between polymorphism rs9839776 in lncRNA sex-determining region Y-box 2

overlapping transcript (SOX2OT) and the risk of gastric cancer (GC) and GC subgroups via a case-control study.

TaqMan genotyping assay was used to perform the genotyping of polymorphism rs9839776 in SOX2OT. The
rs9839776 CT/TT genotype and T allele showed significant association with a decreased risk of GC (CT/TT: adjusted
OR = 0.72, 95% CI = 0.52-1.00, P = 0.046; T: adjusted OR = 0.74, 95% CI = 0.56-0.99, P = 0.044). Stratified analysis

also revealed that CT and CT/TT genotypes, and T allele of rs9839776 was significantly associated with a decreased
risk of GC showing LNM negative (CT: adjusted OR = 0.67, 95% CI = 0.45-0.99, P = 0.044; CT/TT: adjusted OR =

0.67, 95% CI = 0.46-0.98, P = 0.039; T: adjusted OR = 0.71, 95% CI = 0.51-1.00, P = 0.0491) and GC in tumor stage
I+II (CT: adjusted OR = 0.65, 95% CI = 0.45-0.95, P = 0.028; CT/TT: adjusted OR = 0.66, 95% CI = 0.50-0.96, P =

0.028; T: adjusted OR = 0.71, 95% CI = 0.52-0.99, P = 0.041). Our study suggests that rs9839776 polymorphism in
SOXTOT protective effect for GC and contribute to the development of GC.