Page 6 - J. Chromatin remodeling and epigenetics

[J. Chromatin remodeling and epigenetics-3]

Lysine-specific demethylase 3A is important for autophagic

occurrence

Jisu Park¹, Minsol Jeon¹, Hyunkyung Kim¹

¹Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 02841, Republic

of Korea

Autophagy is an essential process to maintain cell survival and homeostasis under various stress conditions. Here,
we report that lysine-specific demethylase 3A (KDM3A) plays an important role in starvation-induced autophagy.

Using Kdm3a knockout mice, we demonstrate that KDM3A is crucial for proper hepatic autophagy in vivo. Hepatic

mRNA expression analysis and ChIP assay in WT and Kdm3a knockout mouse livers reveal that KDM3A activates
autophagy genes by reducing histone H3K9me2 levels upon fasting. Together, our finding represents previously
unidentified function of KDM3A as a key regulator of autophagy, implicating potential therapeutic approaches for

autophagy-related diseases.