Page 2 - D. Cancer biology

[D. Cancer biology-1]

Understanding functional roles of FAM86A in NF-kB

mediated gastric tumorigenic responses

Yo Han Hong¹, Jieun Oh¹, Wooram Choi¹, Han Gyung Kim¹, Deok Jeong¹, Chaoran Song¹, Long You¹,

Jae Youl Cho¹˙*

¹Integrative biotechnology, Sungkyunkwan University, Suwon 16419, Korea

FAM86A as a non-histone protein lysine methyltransferase has novelty and conserved sequence in the various

species. In this study, we investigated functional roles of FAM86A on the gastric tumorigenic responses. According
to microarray analysis against Asian Cancer Research Group, FAM86A was significantly overexpressed in tumor

compared to normal. Also, FAM86A overexpressed gastric cancer patient’s prognosis was known to be worse than
control group. FAM86A was occurred genetic alteration in the cancer patients. FAM86A was overexpressed in most

gastric tumor tissue and cancer cell lines. Moreover, FAM86A involved in various tumorigenic responses including
cell proliferation, cell cycle, invasion, migration and colony formation. And then, we figured out the mechanism by

which FAM86A regulates gastric tumorigenic responses. As results, FAM86A activated FGFR1, a novel binder partner
of FAM86A, mediated NF-kB signaling pathway by the methylation dependent manner. FAM86A regulated tumor

growth and metastasis in vivo mice model. These results suggest that FAM86A could regulate gastric tumorigenic
responses through FGFR1 mediated NF-kB signaling pathway by the methylation dependent manner.