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[F. Others] F-17

Impact of X-ray Irradiation on Blood Cells using Compact

Ceramic Vacuum Tube based on Fast Pulsing Technology for

Blood Irradiator

Jinho Choi¹, Hanna Lee², Jaekyu Jang³, Kyung-Sik Yoon⁴, Moonkyoo Kong⁵, Jehwang Ryu⁶*

¹Department of Radiation Oncology, College of Medicine, Kyung Hee University, Seoul 02447, Korea, ²Department

of Age Service-Tech Convergence, College of Medicine, Kyung Hee University, Seoul 02447, Korea, ³R&D, CAT

Beam Tech Co., Seoul 02455, Korea, ⁴Department of Biochemistry and Molecular Biology, College of Medicine,
Kyung Hee University, Seoul 02447, Korea, ⁵Department of Radiation Oncology, Kyung Hee University Medical
Center, Seoul 02447, Korea

X-ray irradiation of blood components is used to prevent transfusion-associated graft-versus-host disease (TA-
GVHD). When TA-GVHD occurs, clinical symptoms such as fever, rash, pancytopenia, liver dysfunction, edema, and

systemic blisters appear within 10 to 12 days after transfusion. Once the disease develops, there is no effective
treatment, so prevention is essential. In order to prevent graft-versus-host disease caused by blood transfusion, X-

ray irradiation is performed on blood products. Medical institutions have facilities with blood irradiators for the
irradiation of blood components and use a dose of 20 to 50 Gy. In this study, we developed a compact vacuum X-
ray tube sealed by the ceramic body instead of a glass envelope. The monoblock was tested when high voltage

around 70kV and tube current around 2 mA is applied. Also, Piranha Multimeter was used to measure kVp, Time,

HVL, Total Filtration, Dose, and Dose rate. After the characteristics of the X-ray tube were obtained, the X-ray was
irradiated to blood cells. In this study, we propose a method to reduce unnecessary doses to medical staff by
irradiating X-rays with a digital radiation source.