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P. 177
miR-181a regulates cancer stemness in triple-negative
breast cancer via regulation of ATG5 and/or ATG2B
Jee Won Park, Yesol Kim, Soo-been Lee, Yejin Ko, Jiwon Baek, Minyeong Lee,
Je Yeong Ko and Jong Hoon Park
Department of Biological Science, Sookmyung Women’s University,
Seoul, 04310, Republic of Korea
Graphical Abstract ▼ Figure 2. miR-181a is upregulated in TNBC CSCs and
directly targets autophagy genes.
Results
▼ Figure 1. The expression of autophagy flux and cancer
stemness in breast CSCs. ▼ Figure 3. Inhibition of miR-181a led to changes in
autophagy and cancer stemness.
▼ Figure 4. Recovery of autophagy by curcumin inhibits
cancer stemness in TNBC. ▼ Figure 5. Treatment with curcumin enhances the
suppression of cancer stemness by miR-181a inhibitor.
