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[F. Others] F-8

Investigation of the role of senescent macrophage in

colorectal Carcinogenesis

So Yeong Eom²,³, So Hyun Park¹,², YoungHwa Kim²*, Jang-Hee Kim¹,²*

¹Pathology, Ajou University School of Medicine, Suwon 16499, Korea, ²Inflamm-Aging Translational Research

Center, Ajou University Medical Center, Suwon 16499, Korea, ³Biomedical Sciences, Ajou University Graduate

School of Medicine, Suwon 16499, Korea

Macrophages are a diverse group of white blood cells known for eliminating pathogens through phagocytosis.
According to the activation state and functions of macrophages, they can be divided into M1-type (classically

activated macrophage) and M2-type (alternatively activated macrophage) Especially M2 was tumor-associated
macrophages (TAMs) are the key cells that create an immunosuppressive tumor microenvironment (TME). We found

an interesting senescent (p16 positive) or non-senescent (p16 negative) M2 were located in a colorectal tumor, p16
was a general senescent cell marker. We previously published that senescent tumor cells were found in many types

of tumor and it is related to the tumor microenvironment. The in vitro result shows that senescent tumor induced
p16 positive m2 like macrophage phenotype might be closely related with tumor microenvironment. We discuss

and prospect the potential applications of p16 positive m2 like macrophage strategies in the colorectal
carcinogenesis environment and the clinical cancer treatment based on the result.