Page 34 - A. Aging

[A. Aging-19]

Standardization of visual phenotype in aging mice

Hae-Sol Shin¹˙²˙#, Jinu Han¹˙#, Hong Kyung Kim², Yejin Cho³, Soo Jung Han¹, Jiyeon Kim¹˙⁵,

Jihei Sara Lee¹, Hyoung-Chin Kim⁴, Ki Taek Nam³, Kyoung Yul Seo¹˙²˙⁵˙*

¹Department of Ophthalmology, Yonsei University College of Medicine, Seoul 03722, Korea, ²Korea Mouse Sensory
Phenotyping Center (KMSPC), Yonsei University College of Medicine, Seoul 03722, Korea, ³Severance Biomedical

Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea, ⁴Laboratory Animal Resource Center,

Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea, ⁵Brain Korea 21 Plus Project
for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea

To standardization of the visual function and anatomical changes in the eyes of old mice as research models for

human senile eye disease. A analysis of data on middle aged and old C57BL/6J mice was performed, using
optokinetic nystagmus (OKN), fundus photograph, optical coherence tomography (OCT), and electroretinogram

(ERG). Data were acquired at 16 weeks, 48 weeks, and 96 weeks. The retinal function and clarity of lens were
relatively preserved until 48 weeks of age in mice. however they significantly deteriorated at 96 weeks of age. This

study helped characterize aged eyes for future studies on senile eye diseases such as naturally occurring cataract
and age-related macular degeneration.