Page 18 - ebook

[A. Biochemistry/Molecular Biology] A-9

Peptide Programming Of Nanoparticle As A Theranostic

Toolbox Towards Anti-atherosclerosis

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Seung Eun Yu¹ , Seyong Choung¹ , Young Min Shin¹, Hyo-Jin Yoon¹, Sunghyun Lee¹, Kyubae Lee¹, Suk
Kyoung Kim¹, Hyun-Su Ha¹, Hye-Seon Kim¹, Sewoom Baek¹, Si Young Kim¹, Hak-Joon Sung¹*

¹Department of Medical Engineering, Yonsei University College of Medicine, Seoul 03722, Korea

Continuous progress has been made in the field of nanodelivery to enable diagnosis and therapy together

(“theranostic”) and to set nanoparticle as major depot and vehicle of therapeutics. Increasing demands lie in
improving the therapeutic potential because currently, nanoparticle themselves are used as the sole spot to load

therapeutics. When peptides are displayed on nanoparticles, the peptides can serve as not only a navigator to find
a molecular zip code but also a potent therapeutic to improve synergistically with inter-nanoparticle contents.

Moreover, this peptide strategy improves the diagnostic power due to the zip code targeting in addition to saving
a room to load diagnostic agents in nanoparticles. When applied to a vascular system, this strategy appears to be

more effective because atherosclerosis occurs in an irreversible cascade fashion and thus, requires a theranostic
tool as a last option to treat, representing a breakthrough point of the present study.