Page 140 - ebook

[B. Cell Biology/Stem Cell] B-5

Ablation of Sirt1 in the non-hematopoietic bone marrow

microenvironment is not required for hematopoietic stem

cell function in the adult mice

Suyeon Woo¹, Jayoung Kim¹, Hee Sun Choi¹, Munju Kwon¹, Dongjun Lee¹*

¹Department of Convergence Medicine, Pusan National University, Yangsan 50612, Korea

SIRT1 is known as a histone deacetylase, performs a wide variety of function in biological systems. It has been
reported that SIRT1 is relevant to stem cell homeostasis including cell proliferation, differentiation, apoptosis, and

inflammatory responses. Also this SIRT1 plays a important role in delay aging, extending life span and prevent
aging-related in response to mitochondrial metabolic. The previous study demonstrated that loss of Sirt1 in the

hematopoietic stem and progenitor system regulates the expansion of hematopoietic stem and progenitor cell
population under stress conditions. In addition, SIRT1 activator regulates hematopoeitic stem and progenitor cell

and changed the number fo hematopoietic stem cell. This study investigated the role of SIRT1 in the non-
hematopoietic bone marrow microenvironment. Ablation of Sirt1 in the non-hematopoietic bone marrow

microenvironment demonstrated that the production of mature blood cells and frequencies of hematopoietic stem
and progenitor cell population attained similar results to those of controls. Moreover the ablation of Sirt1 in the
non-hematopoietic bone marrow microenvironment had no influence on stem cell function under stress conditions.

Thus, SIRT1 is dispensable for regulating pools of hematopoietic stem and progenitor cells.