Page 1 - W. RNA biology

Medulloblastoma-associated DDX3 variant selectively alters the translation response to stress

Sekyung Oh 1* , Ryan A Flynn 2 , Stephen N Floor 3 , Jennifer A Doudna 3 , Howard Y Chang 2 , Yoon-Jae Cho 1,4
1 Catholic Kwandong University, South Korea, 2 Stanford University, USA, 3 University of California, Berkeley, USA, 4 Oregon Health & Science University, USA,
* Correspondence: ohskjhmi@gmail.com

A C

D
B

solvent accessibility
425 Buried Solvent Exposed 25
eak
534
SG
A H R V R T AR A
A G
I
V
A
A
0
1 132 07 2 5
DDX3X 3
R A
Hu an 40
B C D l ent ace
Du le un in ing Du le un in ing ATP r l i
m
A B C

A FLAG-tagge B D
c n truct
Marker DDX3X WT DDX3X R534H
r Rluc
250
150
100
75 FLAG-DDX3X
C
50
37 FLAG-Rluc
25
20
15
anti-FLAG IP
il er tain
A B
A B
C

C D