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[E. Immunology] E-1 Hydrophobic Cell Penetrating Peptide-Combined Nuclear Localization Signal Suppresses Pro-Inflammatory Cytokines In Inflammatory Bowel Disease Seokwon Lee1, Jaehyeon Kim1, Hyunji Lee1, Hyeontae Kang1, Mingu Kang1, Eunhee Yang1, Eunna Chung1, Daewoong Jo1* 1Immune Disease Team, Cellivery Therapeutics, Inc., Seoul 03929, Korea Inflammatory bowel disease (IBD) includes two types of inflammatory diseases, ulcerative colitis (UC) and Crohn’s disease (CD).

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Diversity of Non-human Glycan Antigen Expression in Porcine as Xenograft Model 1,2 Ji Eun Park , Myung Jin Oh 1,2 , and Hyun Joo An 1,2* 1 Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, 34134, Korea 2 Asia-pacific Glycomics Reference Site, Daejeon, 34134, Korea Overview Xenotransplantation is a solution to bridge the gap between patients with severe organ failures and donors, but differences in glycosylation between humans and pig act as an immune barrier.

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Systemically-Delivered Nuclear Localization Signal Has Therapeutic Potential To Treat Sepsis By Suppressing Cytokine-Storm Gyunam Kim, Dongho Kim, Sanghyeon Yu, Misuk Baek, Jaewook Lee, Eunna Chung and Daewoong Jo Cellivery R&D Institute, Cellivery Therapeutics, Inc., Seoul 03929, Korea. BACKGROUND AIM Infection activates innate immunity to generate pro-inflammatory This study suggests that improved Cell-Permeable nuclear import cytokines and cause inflammation.

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[E. Immunology] E-8 Entinostat suppresses contact hypersensitivity by inducing IL- 10+ regulatory B cells Minseong Kang1, Hyuk Soon Kim1,2* 1Department of Health Sciences, The Graduate of Dong-A University, Busan 49315, Korea, 2Department of Biomedical Science, Dong-A University, Busan 49315, Korea IL-10+ regulatory B (Breg) cells play a vital role in regulating the immune responses in experimental autoimmune encephalomyelitis, colitis, and contact hypersensitivity (CHS).

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[E. Immunology] E-11 DNA-PKcs regulates immune signaling triggered by mitochondrial DNA double-stranded Breaks June Heo1,2, Ho-Soo Lee1, Hyeseong Cho1,2* 1Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea, 2Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Korea Mitochondrial DNA (mtDNA) encodes necessary genes for the generation of ATPs (adenosine triphosphates), which are used as an energy source for intracellular activities.

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The role of reactive oxygen species (ROS) in hematopoietic stem cells engraftment Minji Choi , Mina Boo , Woo Yong Park , Gahee Song , Ja Yeon Park , Se Jin Jung , Jinbong Park , Jae-Young Um , 2,3 1,3 2,3 2,3 2,3 2,3 2,3 Hyun Jeong Kwak 1* 1 Department of Natural Science, College of Convergence and Integrated Science, Kyonggi University, Suwon 16227, Korea 2 Department of sience of Korean Medicine, Graduate school, Kyung Hee University, Seoul 02447, Korea 3 Department of pharmacology, Collage of Korean Medicine, Kyung Hee University, Seoul 02447, Korea ABSTRACT RESULTS Hematopoietic stem…

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